منابع مشابه
Morphological heterogeneity in childhood B cell acute lymphoblastic leukaemia.
Considerable heterogeneity of lymphoblast morphology in childhood B cell acute lymphoblastic leukaemia has been observed. One case showed unusual monocytic features and emphasised the need for marker studies in the accurate definition of acute lymphoblastic leukaemia phenotypes. B cell acute lymphoblastic leukaemia is rare but may have been previously underestimated by morphological misinterpre...
متن کاملIncreased soluble HLA-DRB1in B-cell acute lymphoblastic leukaemia.
Soluble HLA (sHLA) are potential tumour markers released in order to counter immune surveillance. sHLA-class II is less known especially in acute lymphoblastic leukaemia (ALL). This study aimed to investigate soluble, surface and allelic expression of HLA Class II (sHLA-DR) in B-cell ALL patients and compare with soluble expression in normal individuals. A sandwich enzyme-linked immunosorbent a...
متن کاملPediatric B Cell Acute Lymphoblastic Leukemia presenting with Paraneoplastic Acute Disseminated Encephalomyelitis
Acute Disseminated Encephalomyelitis (ADEM) is a monophasic demyelinating disease most often triggered by infection or immunization, though associations with malignancy and stem cell transplant have been described. We described the case of a four-year-old boy with new-onset neurological symptoms associated with ADEM, acute leukemia, and equivocal evidence of Mycoplasma pneumoniae infection. He ...
متن کاملThe cancer stem cell model: B cell acute lymphoblastic leukaemia breaks the mould
The cancer stem cell (CSC) hypothesis postulates that tumours are arranged in a developmental hierarchy reflecting heterogeneity on the cellular level. Within a given tumour, only a subset of cells have the capacity to self-renew, give rise to more differentiated progeny and maintain the tumour long-term (Nguyen et al, 2012). The model implies that cancer therapy must eliminate all CSCs in orde...
متن کاملt(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL)
Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we report the translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 BCP-ALL patients. Fluorescence in situ hybridization and long-distance inverse pol...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1989
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.1989.tb07700.x